Human G-Protein Coupled Receptor
AssigneeHuman Genome Sciences, Inc.
InventorsYi Li, Craig A. Rosen
Life of this patent
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Abstract
A human G-protein coupled receptor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for identifying antagonists and agonists to such polypeptide. Antagonists and agonists may be used therapeutically to inhibit or stimulate the G-protein coupled receptor. Also disclosed are assays for detecting mutations in the nucleic acid sequence encoding the G-protein coupled receptor.
Claims20
An isolated polynucleotide comprising a member selected from the group consisting of:
- (a) a polynucleotide encoding the polypeptide comprising amino acid as set forth in SEQ ID NO:2;
- (b) a polynucleotide capable of hybridizing to and which is at least 70% identical to the polynucleotide of (a);
- and
- (c) a polynucleotide fragment of the polynucleotide of (a) or (b).
An isolated polynucleotide comprising a member selected from the group consisting of:
- (a) a polynucleotide encoding a mature polypeptide encoded by the DNA contained in ATCC™ Deposit No. 75982;
- (b) a polynucleotide encoding a polypeptide expressed by the DNA contained in ATCC™ Deposit No. 75982;
- (c) a polynucleotide capable of hybridizing to and which is at least 70% identical to the polynucleotide of (a) or (b);
- and
- (d) a polynucleotide fragment of the polynucleotide of (a), (b) or (c).
A receptor polypeptide comprising a member selected from the group consisting of:
- (a) a polypeptide having the deduced amino acid sequence of SEQ ID NO:2 and fragments, analogs and derivatives thereof;
- and
- (b) a polypeptide encoded by the cDNA of ATCC™ Deposit No. 75982 and fragments, analogs and derivatives of said polypeptide.
Dependencies are inferred from the claim text.