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AssigneeEuroscreen S.A.
InventorsValerie Wittamer, J. F. Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Marisa Vulcano, Jean-Denis Franssen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul, Cecile Loison, Frederic Ooms, Silvano Sozzani
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The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
A polypeptide comprising an amino acid sequence N1N2X1X2X3N3X4N4×5, wherein N1 and N2 are aromatic or hydrophobic amino acids, N3 and N4 are aromatic amino acids, and X1-X5 are any amino acids, and wherein the polypeptide binds specifically to a ChemerinR polypeptide.
Dependencies are inferred from the claim text.