Combination Therapy for the Treatment of Cancer
OwnerVladimir Ratushny, Erica Golemis +3inventors
InventorsVladimir Ratushny, Erica Golemis, Igor Astsaturov, Iiya G. Serebriiskii, Louis M. Weiner
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Abstract
Compositions which act synergistically to inhibit the growth of cancer cells and methods of use thereof are disclosed.
Claims18
A method for modulating tumor growth or metastasis in a subject in need thereof, comprising sequential or simultaneous administration of at least one Aurora kinase inhibitor and at least one EGFR inhibitor in amounts effective therefore, said method optionally comprising administration of at least one anti-proliferative agent.
A pharmaceutical composition for modulating tumor growth or metastasis in a subject in need thereof, comprising an effective amount of at least one Aurora kinase A inhibitor and at least one EGFR inhibitor, in a pharmaceutically acceptable carrier.
A plurality of pharmaceutical compositions for combined administration for modulating tumor growth or metastasis in a subject in need thereof, comprising at least one Aurora kinase A inhibitor and at least one EGFR inhibitor, in amounts effective therefore in separate pharmaceutically acceptable carriers, said composition optionally comprising an effective amount of at least one antiproliferative agent.
Dependencies are inferred from the claim text.