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US 2011/0033460 A1Published application
ANTI-ErbB2 ANTIBODIES
OwnerBrian M. Fendly, Gail Dianne Phillips +2inventors
InventorsBrian M. Fendly, Gail Dianne Phillips, Richard H. Scheuermann, Jonathan W. Uhr
Life of this patent
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Abstract
Anti-ErbB2 antibodies are described which bind to an epitope in Domain 1 of ErbB2 and induce cell death via apoptosis. Various uses for these antibodies are also described.
Claims11
1-41. (canceled)
A method of treating cancer comprising administering to a human subject with cancer characterized by overexpression of the ErbB2 receptor a first antibody that binds Domain 1 (SEQ ID NO:
- 1) of ErbB2 and thereby induces cell death in cancer cells overexpressing ErbB2, or an antigen-binding fragment of said first antibody, and a second antibody that binds ErbB2 at a different domain than Domain 1 and inhibits growth of cancer cells overexpressing ErbB2, or an antigen-binding fragment of said second antibody.
Dependencies are inferred from the claim text.