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AssigneeNovartis Vaccines and Diagnostics, Inc.
InventorsKeting Chu, Lorianne K. Masuoka
Estimating the term…
Methods of therapy for B-cell malignancies are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity when the antibody binds a CD40 antigen on a normal human B cell, exhibits antagonist activity when the antibody binds a CD40 antigen on a malignant human B cell, and can exhibit antagonist activity when the antibody binds a CD40 antigen on a normal human B cell. Antagonist activity of the anti-CD40 antibody or antigen-binding fragment thereof beneficially inhibits proliferation and/or differentiation of malignant human B cells.
A human anti-CD40 monoclonal antibody or an antigen-binding fragment thereof, wherein said anti-CD40 antibody or fragment thereof exhibits antagonist activity when said antibody or fragment thereof binds a CD40 antigen on a malignant human B cell, wherein said human anti-CD40 monoclonal antibody is selected from the group consisting of:
A method for treating a patient with a disease comprising malignant B cells, said method comprising administration of a therapeutically effective amount of a human anti-CD40 monoclonal antibody, an antigen-binding fragment of said antibody, or a conjugated form of said antibody or said antigen-binding fragment to said patient, wherein said anti-CD40 antibody or antigen-binding fragment, or conjugated form thereof, exhibits antagonist activity when said antibody or antigen-binding fragment, or conjugated form thereof, binds a CD40 antigen on a malignant human B cell, wherein said human anti-CD40 monoclonal antibody is selected from the group consisting of:
A method of inhibiting proliferation of malignant cells of B cell lineage, said method comprising contacting said malignant cells with an effective amount of a human anti-CD40 monoclonal antibody, an antigen-binding fragment of said antibody, or a conjugated form of said antibody or said antigen-binding fragment, whereby when said antibody or antigen-binding fragment, or conjugated form thereof, binds to CD40 antigen on said malignant cells, the proliferation of said malignant cells is inhibited, wherein said human anti-CD40 monoclonal antibody is selected from the group consisting of:
Dependencies are inferred from the claim text.