Antibody Against Anthrax Toxins
AssigneeETAT FRANCAIS represente par le Delegue General pour I'Armement
InventorPhilippe Thullier
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Abstract
The invention relates to an anti PA antibody, in which the variable region of the heavy chain has an amino acid sequence represented by SEQ ID N°1 and in which the variable sequence of the light chain has an amino acid sequence represented by SEQ ID N°2, that is modified in order to improve its affinity and its tolerance in human beings.
Claims26
An anti-PA antibody in which the variable region of the heavy chain has an amino acid sequence represented by SEQ ID No.1 and the variable region of the light chain has an amino acid sequence represented by SEQ ID No.2, characterized in that said antibody is modified with at least one mutation selected from G/S (31A), R/K (66), K/R (73), D/G (28), G/E (31A), H/L (55), S/G (74), Y/T (113), S/L (117) in the variable region of the heavy chain, and Q/R (68), Q/R (27), A/P (114), Q/L (68), P/S (115), H/R (24), S/E (69), S/R (58) in the variable region of the light chain, and characterized in that said modified antibody displays an affinity greater than that of the nonmutated antibody.
Dependencies are inferred from the claim text.