Methods for Treating Osteoarthritis Pain By Administering a Nerve Growth Factor Antagonist and Compositions Containing the Same
AssigneeRinat Neuroscience Corp.
InventorsArnon Rosenthal, David Louis Shelton, Patricia Ann Walicke
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Abstract
The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.
Claims85
A method for treating osteoarthritis pain in an individual comprising administering an effective amount of an NGF antagonist to the individual.
A method for improving physical function in an individual having osteoarthritis comprising administering an effective amount of an NGF antagonist to the individual.
A method for improving stiffness in an individual having osteoarthritis comprising administering an effective amount of an NGF antagonist to the individual.
A kit comprises an effective amount of an NGF antagonist and instructions for administering an effective amount of the NGF antagonist to an individual for treating osteoarthritis pain in the individual.
A kit comprises an effective amount of an NGF antagonist and instructions for administering an effective amount of the NGF antagonist to an individual having osteoarthritis for improving physical function in the individual.
A kit comprises an effective amount of an NGF antagonist and instructions for administering an effective amount of the NGF antagonist to an individual having osteoarthritis for improving stiffness in the individual.
A pharmaceutical composition comprising an NGF antagonist and a pharmaceutically acceptable carrier for treating osteoarthritis pain in an individual.
A pharmaceutical composition comprising an NGF antagonist and a pharmaceutically acceptable carrier for improving physical function in an individual having osteoarthritis.
A pharmaceutical composition comprising an NGF antagonist and a pharmaceutically acceptable carrier for improving stiffness in an individual having osteoarthritis.
Dependencies are inferred from the claim text.