Method for Increasing Bone Mass
AssigneeUniversity of Medicine and Dentistry of New Jersey
InventorsElizabeth Moran, Stephen Flowers
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Abstract
The present invention features methods for promoting the differentiation of osteoblast bone forming cells to a mineralization phenotype and increasing bone mass using inhibitors of Brahma. Subjects benefiting from such treatment may have non-union fractures, osteopenia or osteoporosis, osteosarcoma, or a bone graft or bone fusion or orthopedic and dental implants, osteolytic bone disease, skeletal defects or deficiencies or periodontal disease.
Claims16
A method for promoting the differentiation of osteoblast bone forming cells to a mineralization phenotype comprising contacting osteoblast bone forming cells or progenitor cells thereof with an effective amount of an inhibitor of Brahma so that the differentiation of osteoblast bone forming cells or progenitor cells thereof to a mineralization phenotype is promoted.
A method for increasing bone mass, bone healing or bone formation comprising administering to a subject in need of osteoinduction an effective amount of an inhibitor of Brahma thereby increasing bone mass, bone healing or bone formation in the subject.
Dependencies are inferred from the claim text.