Targeted antimicrobials and related compositions, methods and systems

A method to identify an antimicrobial specific for one or more related microorganisms, the method comprising:

• identifying at least one lytic enzyme expressed by a microorganism or by a microorganism related thereto to provide at least one candidate antimicrobial, the at least one lytic enzyme capable of targeting one or more moieties presented on the exterior of the microorganism, the one or more moieties providing the microorganism with structural support and/or protection:
• contacting the at least one candidate antimicrobial with the microorganism for a time and under condition to allow an antimicrobial activity of the at least one candidate antimicrobial on the microorganism:
• and
• selecting among the at least one candidate antimicrobial, a selected candidate antimicrobial having a detectable antimicrobial activity for the microorganism.