Use of adenovirus and nucleic acids coding therefor
OwnerPer Sonne Holminventor
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Abstract
The invention relates to the use of a virus, preferably an adenovirus, for producing a medicament. Said virus is replication-deficient in cells which do not contain YB-1 in the core and codes for an oncogene or oncogene product, especially an oncogene protein, which transactivates at least one viral gene, preferably an adenoviral gene, said gene being selected among the group comprising E1B55kDa, E4orf6, E4orf3, and E3ADP.
Claims21
-55. (canceled)
Use of a virus for the manufacture of a medicament, characterized in that the virus is replication deficient in cells which lack YB 1 in the nucleus, and whereby the virus encodes an oncogene protein which transactivates at least one viral gene, whereby the gene is selected from the group comprising E1B55kDa, E4orf6, E4orf3 and E3ADP.
Use of a virus for replication in cells which exhibit YB 1 in the nucleus, characterized in that the virus is replication deficient in cells which lack YB 1 in the nucleus, and whereby the virus encodes an oncogene protein which transactivates at least one viral gene, whereby the gene is selected from the group comprising E1B55kDa, E4orf6, E4orf3 and E3ADP.
Dependencies are inferred from the claim text.