Compositions and methods for treating and preventing skeletal muscle deficiencies
AssigneesThe Regents of the University of Michigan, Phrixus Pharmaceuticals, Inc.
InventorsRainer Ng, Joseph M. Metzger, Lorraine Reeve, Bruce Markham
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Abstract
The present invention relates to compositions and methods for treating and preventing skeletal muscle deficiencies. In particular, the present invention provides compositions comprising poloxamers (e.g., poloxamer 188-P188) and methods of using the same for treating and preventing skeletal muscle deficiencies and injuries (e.g., dystrophin-deficient skeletal muscle; skeletal muscle having a contraction force deficit; skeletal muscle having a Ca2+ imbalance; skeletal muscle having microtears).
Claims27
A method of treating a subject to prevent or reduce skeletal muscle injury or deficiency, comprising administering to said subject a composition comprising a poloxamer under conditions such that said skeletal muscle injury is reduced or prevented.
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A composition comprising a poloxamer and a second agent useful for the treatment of a skeletal muscle contraction force deficit.
(canceled)
-51. (canceled)
The method of claim 16, wherein a poloxamine and/or a polyglycidol is used instead of, or with, said poloxamer.
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Dependencies are inferred from the claim text.