Hydrazone Compounds and Their Use

A compound having the Formula I:

• or a pharmaceutically acceptable salt or stereoisomer thereof, wherein:
• R2 and R3 are each independently hydrogen or alkyl;
• R4 is aryl, a 6-membered heteroaryl having at least one nitrogen atom, or a 9-10-membered heteroaryl having at least one nitrogen atom, each of which is optionally substituted;
• or
• R4 is phenyl, wherein two adjacent carbon atoms of the phenyl ring form a bridge —O—(CH2)r—O— or —(NR26)—(CH2)s—O— to form a fused bicyclic ring, wherein r and s are 1, 2, or 3, and R26 is H or C1-4 alkyl, and wherein the bicyclic ring is optionally substituted;
• L2 is absent;
• and
• R1-L1- is selected from the following:
• wherein
• R5 is C1-6 alkyl;
• R6 and R7, which can be present in either ring of the indol-3-yl group, are each independently selected from the group consisting of hydrogen, halogen, alkyl, cycloalkyl, alkoxy, alkoxyalkyl, haloalkyl, haloalkoxy, hydroxyalkyl, aminoalkyl, hydroxy, nitro, cyano, amino, alkylamino, dialkylamino, (alkylamino)alkyl, and (dialkylamino)alkyl;
• R8 is independently hydrogen or C1-6 alkyl;
• and
• m is 1, 2, or 3;
• b)
• R1d-cyclopropyl-C(═O)—, wherein
• R1d is optionally substituted phenyl or optionally substituted 6-10-membered heteroaryl having at least one nitrogen atom,
• provided that 1) when R2 and R3 are hydrogen, R4 is unsubstituted phenyl or phenyl substituted with other than one of arylalkoxy or heteroarylalkoxy, and R1d is optionally substituted phenyl, then R1d is substituted by at least one haloalkyl, or 2) when R1d is optionally substituted phenyl, then R4 is other than optionally substituted isoquinolinyl;
• c) R1a—Z —(CHR12)n—C(O)—;
• wherein
• R1a is optionally substituted aryl,
• R12 is independently hydrogen or C1-6 alkyl,
• Z is S, SO, or SO2, and
• n is 1, 2, or 3;
• d) R1b—(CHR13)p—NH—C(O)—;
• wherein
• R1b is alkyl, cycloalkyl, aryl or heteroaryl, each of which is optionally substituted,
• R13 is independently hydrogen or C1-6 alkyl, and
• p is 0, 1, 2, or 3;
• or
• e) R1c—(CHR14)q—C(O)—, wherein
• R1c is optionally substituted indol-1-yl, optionally substituted pyrrolo[2,3-b]pyridin-1-yl, optionally substituted benzoimidazol-1-yl, optionally substituted quinolinyl, or optionally substituted pyridinyl;
• R14 is independently hydrogen or C1-6 alkyl;
• and
• q is 1, 2, or 3