Radio-labeled materials and methods of making and using the same
OwnerJohn V. Frangioni, Preeti Misrainventors
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Abstract
Radio-labeled materials, e.g., compounds and compositions, methods of making the radio-labeled materials, and applications of the same are disclosed. For example, novel solid-state methods are disclosed that produce radio-labeled compositions that include a reactive, but stable radio-labeled compound in a polar anhydrous solvent. The radio-labeled compounds can be readily conjugated with a variety of ligands.
Claims58
A method of making a radio-labeled material, the method comprising:
- combining a chelating material having a conjugatable group or a protected conjugatable group with a radioactive metal-containing material, a reducing agent, a substantially insoluble crosslinked resin, and a solvent to provide a mixture;
- reacting the mixture under conditions and for a time sufficient to produce a radio-labeled chelate having the conjugatable group or the protected conjugatable group;
- and
- separating the radio-labeled chelate from the mixture.
A method of making a radio-labeled material, the method comprising:
- combining a chelating material having a conjugatable group or a protected conjugatable group with a radioactive metal-containing material, and a solvent to provide a mixture;
- reacting the mixture under conditions and for a time sufficient to produce a reaction mixture comprising a radio-labeled chelate having the conjugatable group or the protected conjugatable group;
- and
- separating the radio-labeled chelate from the reaction mixture by passing the reaction mixture through one or more substantially insoluble crosslinked resins.
A radio-labeled composition comprising a radio-labeled chelate having a conjugatable group or a protected conjugatable group dissolved in an anhydrous solvent, wherein a purity of the radio-labeled chelate is greater than 92.5 percent.
A radio-labeled material comprising a compound of Structure I
- wherein
- M is In, Y, Gd, Eu, or a lanthanide;
- and
- R is H, a C1-C10 straight-chain or branched alkyl group, or N-succinimidyl.
A reaction product of
- or an ester or salt thereof, and a metal compound comprising In, Y, Gd, Eu or a lanthanide.
A kit for preparing a radio-labeled material, comprising:
- a chelating material;
- a reducing agent;
- and
- one or more cartridges, wherein the one or more cartridges comprise a substantially insoluble crosslinked resin.
Dependencies are inferred from the claim text.