Methods and computer program products for quantitative three-dimensional image correction and clinical parameter computation in optical coherence tomography

A method for quantitative three-dimensional (“3D”) image correction in optical coherence tomography using a computer readable medium, the method comprising:

• segmenting of index interface refracting surfaces from raw optical coherence tomography (“OCT”) dataset from an OCT system;
• calculating normal vectors or partial derivatives of a curvature at each refracting surface to obtain a refracted image voxel;
• and
• iteratively computing a new position of each desired refracted image voxel;
• interpolating of new refracted corrected voxel positions to an even sampling grid to provide corrected image data.

A computer program product comprising computer executable instructions embodied in a computer readable medium for performing steps comprising:

• segmenting of index interface refracting surfaces from raw optical coherence tomography (“OCT”) dataset from an OCT system;
• calculating normal vectors or partial derivatives of a curvature at each refracting surface to obtain a refracted image voxel;
• iteratively computing a new position of each desired refracted image voxel;
• interpolating of new refracted corrected voxel positions to an even sampling grid to provide corrected image data;
• and
• computing clinical outputs from the corrected image data.