Synthesis of water-soluble organic nanoparticles as epr standard
AssigneeUniversity of Florida Research Foundation, Inc.
InventorsY. CHARLES CAO, Ou Chen, Alexander Angerhofer
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Abstract
Novel water soluble paramagnetic organic nanoparticles are formed by a novel method where an organic solution of an organic compound is injected into water under agitation that is maintained for a desired period of time for nanoparticle growth followed by termination of the growth by the addition of an aqueous surfactant solution. The size of the nanoparticles depends on the time between injection and addition of the surfactant solution. In embodiments of the invention, the water soluble paramagnetic organic nanoparticles can be DPPH nanoparticles, DPPH nanoparticles doped with DPPH-H, or core/shell nanoparticles where a DPPH core is covered by a DPPH-H shell.
Claims20
A water soluble paramagnetic nanoparticle comprising 2,2′-diphenyl-1-picrylhydrazyl (DPPH) with a diameter of 5 to 1,000 nm.
A method for preparation of a water soluble paramagnetic nanoparticle comprising the steps of:
- providing an organic solution comprising a paramagnetic organic compound and a water miscible organic solvent;
- injecting said organic solution into agitated water to form a growth solution;
- maintaining said agitation of said growth solution for a period of time wherein a plurality of nanoparticles of said paramagnetic organic compound grow in size;
- injecting an aqueous surfactant solution into said growth solution, wherein said plurality of said nanoparticles size is fixed by said period of time;
- and
- isolating said plurality of said nanoparticles.
Dependencies are inferred from the claim text.