US 2011/0020406 A1 · VIRAL INACTIVATION PROCESS

Abstract

The invention relates generally to the field of virology. More particularly, the present invention relates to methods for determining the effect of a viral inactivation procedure on the antigenicity of the inactivated virus. In particular for a virus that is a member of the family Arteriviridae or Coronaviridae or Asfarviridae, in particular for Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). The invention further provides methods to determine the antigenicity of an inactivated virus as well as methods to screen for anti-viral compounds using any one of the aforementioned methods Methods of using the inactivated and immunogenic virus thus obtained, in particular in the manufacture of a vaccine are also provided by the present invention.

Claims21

Dependent claims

A method of determining an inactivated virus's antigenicity, said method comprising;

contacting a host cell with an inactivated virus to be tested;
and
determining the binding to and/or the internalization into the host cell and/or the fusion of said inactivated virus;
wherein the capability of said inactivated virus to bind to and/or to enter and/or to fuse with the host, is indicative of the antigenicity of said inactivated virus.

1 more element

Dependencies are inferred from the claim text.

Viral inactivation process

Life of this patent

Viral inactivation process

Life of this patent

Abstract

Claims21