Breast cancer expression profiling

A polynucleotide library that molecularly characterizes a cancer comprising or corresponding to at least one, or at least 2, or at least 3, or at least 4, or at least 5, or at least 6, or at least 7, or at least 8, or at least 9, or at least 10, or at least 11, or at least 12, or at least 13, or at least 14, or at least 15 of the 16 genes encoding serine/threonine kinases listed in Table 1, or to said 16 genes.

A method for screening molecule for treating luminal A cases of poor prognosis comprising the analysis of the action of said molecule on at least one, or at least 2, or at least 3, or at least 4, or at least 5, or at least 6, or at least 7, or at least 8, or at least 9, or at least 10, or at least 11, or at least 12, or at least 13, or at least 14, or at least 15 of the 16 kinases listed in table 1 or their expression, or on said 16 kinases.

A method for predicting clinical outcome for a patient diagnosed with cancer, comprising determining the expression level of at least one, or at least 2, or at least 3, or at least 4, or at least 5, or at least 6, or at least 7, or at least 8, or at least 9, or at least 10, or at least 11, or at least 12, or at least 13, or at least 14, or at least 15 of the 16 genes listed in Table 1, or all of the 16 genes of Table 1, or their expression products, in a cancer tissue or cell obtained from the patient, normalized against a control gene or genes, and compared to the amount found in a reference cancer tissue set, wherein overexpression of the group of genes predicts a poor clinical outcome.

A method of predicting the likelihood of the recurrence of cancer following treatment in a cancer patient, comprising determining the expression level of at least one, or at least 2, or at least 3, or at least 4, or at least 5, or at least 6, or at least 7, or at least 8, or at least 9, or at least 10, or at least 11, or at least 12, or at least 13, or at least 14, or at least 15 of the 16 genes listed in Table 1, or all of the 16 genes of Table 1, or their expression products, in a cancer tissue obtained from the patient, normalized against a control gene or genes, and compared to the amount found in a reference cancer tissue set, wherein overexpression of the group of genes indicates increased risk of recurrence following treatment.

Method for predicting therapeutic success of a given mode of treatment in a subject having cancer, comprising

• (i) determining the pattern of expression levels of at least one, or at least 2, or at least 3, or at least 4, or at least 5, or at least 6, or at least 7, or at least 8, or at least 9, or at least 10, or at least 11, or at least 12, or at least 13, or at least 14, or at least 15 of the 16 genes encoding serine/threonine kinases listed in Table 1, or of said 16 genes,
• (ii) comparing the pattern of expression levels determined in (i) with one or several reference pattern(s) of expression levels,
• (iii) predicting therapeutic success for said given mode of treatment in said subject from the outcome of the comparison in step (ii).