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US 2010/0330111 A1Published application
Increase of immune response and targeting by antigens and/or drug linkage
AssigneeWittycell
InventorVincent Serra
Life of this patent
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Abstract
The present invention relates to compounds consisting of glycolipids covalently bound to an antigen or a drug via a linker. The said compounds are able to induce a stronger immune response than a composition comprising separated glycolipids and antigen. The said compounds are also able to target drug to CD1d restricted cells.
Claims17
A compound having Formula (I):
- wherein,
- R1, R2, R3, and R4 are each independently hydrogen, C1-C6 alkyl, C6-C12 aralkyl, or C1-C6 acyl;
- and R1 is either above or below the sugar ring;
- R6 is a) —(CH2)xCH3 where x is an integer selected from 1 to 100;
- or
- b) —(CH2)xCH═cH(CH2)yCH3 or —(CH2)xCH═CH(CH2)yCH═CH(CH2)zCH3
- wherein x, y and z are integers independently selected from 1 to 14;
- R5 is one of the following formulae (II), (III) or (IV)
- wherein R8 is hydrogen, C1-C6 alkyl, C6-C12 aralkyl, or C1-C6 acyl, and
- R7 is a linear or branched C3-C100 alkyl;
- X is —O, N or S;
- Y is a cleavable or non-cleavable linker group;
- and
- Z is an antigen or a drug or a pharmaceutically acceptable salt thereof.
11 more elements
Dependencies are inferred from the claim text.