A method for the treatment and prevention of neuropathic pain, inflammatory pain and migraine-associated pain comprising administering to a patient in need of such treatment an effective amount of a compound selected from the group consisting of compounds according to Formulas A, B, C, D, I, III, or IV or a salt thereof,
- wherein Y and Z are taken together with the two intervening carbon atoms to form a ring selected from phenyl and thienyl, which ring is substituted at the C(8) position with at least the substituent —C≡C—R, where R is H, Si(CH3)3, t-butyl, isopropyl, methyl, or cyclopropyl;
- R2 is a substituted or unsubstituted at least partially unsaturated 5 or 6 membered cyclic or heterocyclic ring, wherein if substituted the substituent is one or more of F, Cl, Br, or NO2 at the 2′-position;
- and R10 is N, CH, C—CO2—R5,
- where n is 0 to 4 inclusive,
- where n is 1 or 2 inclusive,
- wherein Y′ and Z′ are taken together with the two intervening carbon atoms to form a ring selected from phenyl and thienyl, which ring is substituted at the C(8)′ position with at least the substituent —C≡C—R′, where R′ is H, Si(CH3)3, t-butyl, isopropyl, methyl, or cyclopropyl;
- R5 is a branched or straight chain C1 to C4 halogenated or unhalogenated alkyl or a methyl cyclopropyl;
- R6 is a branched or straight chain C1 to C4 alkyl or a methyl cyclopropyl;
- R1′ is one of H, CH3, CF3, CH2CF3, CH2CH3, or cyclopropyl;
- R2′ is a substituted or unsubstituted at least partially unsaturated 5 or 6 membered cyclic or heterocyclic ring, wherein if substituted the substituent is one or more of F, Cl, Br, or NO2 at the 2′-position;
- and wherein when R10 is C—CO2—R5, R1 is one of H, CH3, CF3, CH2CF3, CH2CH3, CH2C≡CH, or cyclopropyl;
- otherwise, R1 is one of H, CH3, CF3, CH2CH3, CH2CF3, or cyclopropyl;
- and wherein when R10 is
- B is O or NH and wherein —BCH2B— is optionally replaced with —N(R7)—N(R7)—, where R7 is one of H, CH3, alkyl, or cycloalkyl;
- and when R10 is
- B is O or NH or —N(R7)—N(R7)—, where R7 is one of H, CH3, alkyl, or cycloalkyl;
- and R9 is N or
- wherein when R9 is
- R1 is ═O and R10 is N;
- R3 is one of —H, —OH, —OCON(CH3)2, —COOH, —COOCH3, —COOC2H5,
- wherein if R3 is
- n is 0 to 4;
- Y′ and Z′ are taken together with the two intervening carbon atoms to form a ring selected from phenyl and thienyl, which ring is substituted at the C(7)′ position with at least the substituent —C≡C—R′, where R′ is H, Si(CH3)3, t-butyl, isopropyl, methyl, or cyclopropyl;
- R1 and R1′ are independently one of H, CH3, CF3, CH2CF3, CH2CH3, or cyclopropyl;
- R2 and R2′ are independently a substituted or unsubstituted at least partially unsaturated 5 or 6 membered cyclic or heterocyclic ring, wherein if substituted the substituent is at least one of F, Cl, Br, or NO2 at the 2′-position, or
- wherein if R3 is
- Y′ and Z′ are taken together with the two intervening carbon atoms to form a ring selected from phenyl and thienyl, which ring is substituted at the C(7)′ position with at least the substituent —C≡C—R′, where R′ is H, Si(CH3)3, t-butyl, isopropyl, methyl, or cyclopropyl;
- R1 and R1′ are independently one of H, CH3, CF3, CH2CH3, CH2CF3 or cyclopropyl;
- R2 and R2′ are independently a substituted or unsubstituted at least partially unsaturated 5 or 6 membered cyclic or heterocyclic ring, wherein if substituted the substituent is at least one of F, Cl, Br, or NO2 at the 2′-position;
- B is O or NH and wherein —BCH2B— is optionally replaced with —N(R7)—N(R7)—, where R7 is one of H, branched or straight chain C1 to C4 alkyl, cyclopropyl or methyl cyclopropyl,
- wherein if R3 is
- Y′ and Z′ are taken together with the two intervening carbon atoms to form a ring selected from phenyl and thienyl, which ring is substituted at the C(7)′ position with at least the substituent —C≡C—R′, where R′ is H, Si(CH3)3, t-butyl, isopropyl, methyl, or cyclopropyl;
- R1 and R1′ are independently one of H, CH3, CF3, CH2CH3, CH2CF3 or cyclopropyl;
- R2 and R2′ are independently a substituted or unsubstituted at least partially unsaturated 5 or 6 membered cyclic or heterocyclic ring, wherein if substituted the substituent is one or more of F, Cl, Br, or NO2 at the 2′-position;
- B is O, NH, or —N(R7)—N(R7)—, where R7 is one of H, branched or straight chain C1 to C4 alkyl, cyclopropyl or methyl cyclopropyl, wherein R2 is not phenyl when R3 is H, R1 is H or CH3 and Y and Z taken together form a phenyl ring;
- wherein R8 is C═O, C═S, or C—NHCH3;
- R11 is O or N and R4 is H, O or C,
- wherein when R11 is O, R4 is H, and R8 is C═O;
- when R11 is N, R4 is C and R11 and R4 are taken together with an intervening nitrogen atom to form a pyrazole ring;
- when R11 is N, R4 is O and R11 and R4 are taken together with an intervening carbon atom to form an oxazole ring;
- or
- when R11 is N, R4 is C and R11 and R4 are taken together with two intervening carbon atoms to form a pyridine ring;
- and R12 is N or CH, R13 is phenyl, 2-thienyl, 3-thienyl, 2-pyridyl, or 2-pyridyl N—O, and if the compound is according to Formula B or C, n is an integer from 1 to 2 inclusive and ring C is saturated or unsaturated.