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OwnerDenis Leclerc, Constantino Roberto López-Macias, IIIinventors
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An antigen-presenting system (APS) comprising one or more enterobacterial antigens in combination with a papaya mosaic virus (PapMV) or a virus like particle (VLP) derived from papaya mosaic virus is provided. The PapMV or VLP included in the APS is capable of potentiating an immune response against said one or more enterobacterial antigens. The APS can be used, for example, as a vaccine against enterobacterial disease, such as typhoid fever. The one or more antigens comprised by the APS can be conjugated to a coat protein of the PapMV or PapMV VLP, or they may be non-conjugated (i.e. separate from the PapMV or PapMV VLP), or the APS can comprise both conjugated and non-conjugated antigens. Conjugation can be, for example, by genetic fusion with the coat protein, or binding via covalent, non-covalent or affinity means.
An antigen-presenting system, comprising one or more enterobacterial antigens in combination with a papaya mosaic virus (PapMV) or a virus-like particle (VLP) derived from a PapMV coat protein, wherein the PapMV or VLP is capable of potentiating an immune response against said one or more enterobacterial antigens.
A polypeptide, comprising a papaya mosaic virus coat protein fused to one or more affinity peptides capable of binding an enterobacterial antigen.
A polypeptid, comprising a papaya mosaic virus coat protein fused to one or more enterobacterial antigens selected from the group of:
-31. (canceled)
A vaccine for immunizing an animal against infection with Salmonella typhi, the vaccine comprising an antigen-presenting system comprising an antigen derived from Salmonella typhi OmpC or OmpF in combination with a papaya mosaic virus (PapMV) or a VLP derived from a PapMV coat protein, wherein the PapMV or VLP is capable of potentiating an immune response against the antigen in the animal.
Dependencies are inferred from the claim text.