Compositions and Methods for Detecting Juvenile Renal Dysplasia or Calcium Oxalate Stones in Dogs
AssigneeDOGenes Inc.
InventorMary Helen Whiteley
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Abstract
The application relates to Canine Cox2 allelic variants associated with Juvenile Renal Dysplasia, primer and probe compositions and methods and kits useful in detecting, monitoring and diagnosing Juvenile Renal Dysplasia or calcium oxalate stones.
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A composition of two or more isolated nucleic acid molecules, the molecules comprising primers that amplify a sequence containing the 5′ untranslated region of canine Cox2 as shown in SEQ ID NO:1, 2, 3, 4 or 5.
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A method of detecting or monitoring juvenile renal dysplasia (JRD) or calcium oxalate stones or a risk of JRD or calcium oxalate stones in a dog comprising detecting the presence of an allelic variant in the 5′UTR of canine Cox2 in a sample from the dog, wherein the presence of the variant is indicative of JRD or calcium oxalate stones or a risk of JRD or calcium oxalate stones in the dog.
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A kit comprising primers that amplify the 5′UTR of a canine Cox2 gene or a probe that hybridizes to the 5′UTR of a canine Cox2 gene and instructions for use in detecting JRD or calcium oxalate stones or a risk of JRD or calcium oxalate stones in a dog.
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Dependencies are inferred from the claim text.