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AssigneesThe Royal Institution for the Advancement of Learn, Ircm (Institut De Recherches Clinques De MontréAl), Mount Sinai School of Medicine
InventorsDeborah Maret, David R. Colman, Eugenia Gruzglin, Nabil Seidah
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The present invention relates to a method for diagnosis and/or prognosis of cancer and for monitoring the progression of cancer and/or the therapeutic efficacy of an anti-cancer treatment in a subject by determining the molecular form of cadherin at the cell surface of cancer cells in the subject. The invention also relates to a method for preventing, inhibiting or treating cancer or its metastasis in a subject by increasing the adhesive forms of cadherin and/or decreasing the non-adhesive forms of cadherin at the cell surface. The invention also relates to a method step of determining the expression level of furin and proprotein convertase 5A (PC5A).
A method for diagnosing or determining prognosis of a cancer in a subject, comprising determining the molecular form of cadherin at the cell surface of cancer cells in the subject, wherein the presence of a non-adhesive form of cadherin or a high ratio of non-adhesive to adhesive forms of cadherin indicates that the cancer is invasive or metastatic.
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A method for monitoring the progression of a cancer in a subject, the method comprising determining the molecular form of cadherin at the cell surface of cancer cells in the subject, wherein the presence of a non-adhesive form of cadherin or a high ratio of non-adhesive to adhesive forms of cadherin indicates that the cancer has progressed to a metastatic phase.
A method for monitoring the efficacy of an anti-cancer treatment in a subject, comprising:
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A kit for diagnosing or determining prognosis of a cancer in a subject, comprising reagents for determining the molecular form of cadherin at the cell surface of cancer cells in the subject, and instructions for use thereof.
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Dependencies are inferred from the claim text.