Modulating production traits in avians
AssigneesCommwealth Scientific and Industrial Research Organization, Australian Poultry Crc Pty Ltd
InventorsTimothy James Doran, Robert John Moore, John William Lowenthal
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Abstract
The present invention relates to methods of modulating traits, particularly production traits, in avians such as chickens. In particular, the invention relates to the in ovo delivery of a dsRNA molecule, especially siRNAs, to modify production traits in commercially important birds.
Claims21
1-24. (canceled)
A method of modifying a trait of an avian, the method comprising administering to an avian egg at least one nucleic acid molecule comprising a double-stranded region, wherein the nucleic acid molecule results in a reduction in the level of at least one RNA molecule and/or protein in the egg.
A method of modifying a trait of an avian, the method comprising administering to an avian egg at least one RNA molecule comprising a double-stranded region (dsRNA), wherein the RNA molecule results in a reduction in the level of at least one RNA molecule and/or protein in the egg, and wherein
- i) the method does not comprise electroporating the egg, and/or
- ii) the RNA molecule is administered to the air sac, yolk sac or chorion allantoic fluid.
An isolated and/or exogenous nucleic acid molecule comprising a double-stranded region which reduces the level of at least one RNA molecule and/or protein when administered to an avian egg.
Dependencies are inferred from the claim text.