Transcutaneous analyte sensor

A device for monitoring a glucose concentration in a host, the device comprising:

• a substantially continuous glucose sensor configured to produce sensor data indicative of a glucose concentration in a host;
• and
• an integrated receiver configured to receive the sensor data from the substantially continuous glucose sensor, wherein the integrated receiver comprises:
• an in vitro single point glucose monitor configured to receive a biological sample from the host and to measure a glucose concentration in the sample;
• a processor module;
• and
• a computer readable memory comprising:
• instructions configured to cause the processor module to calibrate the sensor data received from the substantially continuous glucose sensor;
• instructions configured to cause the processor module to determine a rate of change of the calibrated sensor data;
• instructions configured to determine whether the rate of change is within a range of rates of change delimited by maximum normally sustainable rates of change of glucose in humans;
• and
• instructions configured to cause the processor module to calibrate the sensor data when the rate of change is within the range of rates of change delimited by maximum normally sustainable rates of change of glucose in humans, but not cause the processor module to calibrate the sensor data when the rate of change is outside the range of rates of change delimited by maximum normally sustainable rates of change of glucose in humans.