Medical devices comprising a co-polymer of a modified polyamide and a polycarbonate
AssigneeAbbott Laboratories Vascular Enterprises Limited
InventorGünter Lorenz
Life of this patent
Estimating the term…
Abstract
The present invention refers to medical devices comprising a modified Co-Polymer or to the modified Co-Polymer itself having high flexibility and high stress resistance, especially tensile strength or tear resistance, in addition to the good physical characteristics of a Block-Co-Polymers of a polyamide and a polycarbonate, either polycarbonate diol or polycarbonate diamine.
Claims41
1-40. (canceled)
An implant or medical device, comprising a Co-Polymer producible by polymerizing a modified polyamide with a polycarbonate diol or a polycarbonate diamine, characterized in that the modified polyamide is producible by contacting/mixing one or more pre-polyamides with an at least mono-substituted α,ω-di-carboxylic acid or its alkyl ester or its acyl halides and raising the temperature to above 150° C.
An implant or medical device comprising a Co-Polymer according to general formula X, Xa, Xb or Xc, or XI, XIa, XIb or XIc
- wherein
- A is a divalent, branched or linear, saturated or non-saturated, optionally substituted hydrocarbon chain, with optionally one carbon atom being replaced by NH, O or S;
- A′ is a divalent, branched or linear, saturated or non-saturated, optionally substituted hydrocarbon chain, with optionally one carbon atom being replaced by NH, O or S;
- E is a divalent, branched or linear, saturated or non-saturated, optionally substituted hydrocarbon chain;
- B and B′ independently from one another are selected from H or C1-4-Alkyl;
- v is a natural number between 1 and 24;
- v′ is a natural number between 1 and 24;
- w is a natural number between 1 and 24;
- x is a natural number ≧1;
- y and y′ are independently from one another a natural number ≧1;
- z is a natural number ≧1;
- m and n are independently from each other selected from 0 and a natural number between 1 and 9 and n+m is a natural number between 1 and 9;
- and
- R1 is any radical except hydrogen.
An implant or medical device comprising a Co-Polymer comprising units derived from polyamide-forming monomers, units derived from polycarbonate diols or polycarbonate diamines and units derived from at least mono-substituted α,ω-di-carboxylic acids,
- wherein the polyamide-forming monomers are represented by the following formulas (IX) or (IXa), the polycarbonate diols are represented by the following formulas (VI) or (VIa), polycarbonate diamines are represented by the following formula (VII) or (VIIa) and the at least mono-substituted α,ω-di-carboxylic acids are represented by the following formula (I):
- wherein
- A is a divalent, branched or linear, saturated or non-saturated, optionally substituted hydrocarbon chain, with optionally one carbon atom being replaced by NH, O or S;
- and
- v is a natural number between 1 and 24;
- with
- wherein
- E is a divalent, branched or linear, saturated or non-saturated, optionally substituted hydrocarbon chain;
- B and B′ independently from one another are selected from H or C1-4-Alkyl;
- w is a natural number between 1 and 24;
- z is a natural number ≧1;
- with
- HOOC—(CH2)m—CHR1—(CH2)n—COR2 (I)
- wherein
- m and n are independently from each other selected from a natural number and 0 and n+m is between 1 and 9;
- R2 is selected from OH, halogen or OC1-4-alkyl;
- R1 is any radical except hydrogen.
A co-polymer producible by polymerizing a modified polyamide with a polycarbonate diol or a polycarbonate diamine, characterized in that the modified polyamide is producible by contacting/mixing one or more pre-polyamides with an at least mono-substituted α,ω-di-carboxylic acid or its alkyl ester or its acyl halides and raising the temperature to above 150° C.
A co-polymer according to general formula X, Xa, Xb or Xc, or XI, XIa, XIb or XIc
- wherein
- A is a divalent, branched or linear, saturated or non-saturated, optionally substituted hydrocarbon chain, with optionally one carbon atom being replaced by NH, O or S;
- A′ is a divalent, branched or linear, saturated or non-saturated, optionally substituted hydrocarbon chain, with optionally one carbon atom being replaced by NH, O or S;
- E is a divalent, branched or linear, saturated or non-saturated, optionally substituted hydrocarbon chain;
- B and B′ independently from one another are selected from H or C1-4-Alkyl;
- v is a natural number between 1 and 24;
- v′ is a natural number between 1 and 24;
- w is a natural number between 1 and 24;
- x is a natural number ≧1;
- y and y′ are independently from one another a natural number ≧1;
- z is a natural number ≧1;
- m and n are independently from each other selected from 0 and a natural number between 1 and 9 and n+m is a natural number between 1 and 9;
- and
- R1 is any radical except hydrogen.
A co-polymer comprising units derived from polyamide-forming monomers, units derived from polycarbonate diols or polycarbonate diamines and units derived from at least mono-substituted α,ω-di-carboxylic acids,
- wherein the polyamide-forming monomers are represented by the following formulas (IX) or (IXa), the polycarbonate diols are represented by the following formulas (VI) or (VIa), polycarbonate diamines are represented by the following formula (VII) or (VIIa) and the at least mono-substituted α,ω-di-carboxylic acids are represented by the following formula (I):
- wherein
- A is a divalent, branched or linear, saturated or non-saturated, optionally substituted hydrocarbon chain, with optionally one carbon atom being replaced by NH, O or S;
- and
- v is a natural number between 1 and 24;
- with
- wherein
- E is a divalent, branched or linear, saturated or non-saturated, optionally substituted hydrocarbon chain;
- B and B′ independently from one another are selected from H or C1-4-Alkyl;
- w is a natural number between 1 and 24;
- z is a natural number ≧1;
- with
- HOOC—(CH2)m—CHR1—(CH2)n—COR2 (I)
- wherein
- m and n are independently from each other selected from a natural number and 0 and n+m is between 1 and 9;
- R2 is selected from OH, halogen or OC1-4-alkyl;
- R1 is any radical except hydrogen.
Dependencies are inferred from the claim text.