Hyaluronidase as an adjuvant for increasing the injection volume and dispersion of large diameter synthetic membrane vesicles containing a therapeutic agent
AssigneePacira Pharmaceuticals, Inc.
InventorsWilliam LAMBERT, Jason REXROAD
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Abstract
Embodiments of the invention relate to hyaluronidase as an adjuvant to increase the injection volume and dispersion of large diameter synthetic membrane vesicles containing one or more therapeutic agents. In particular, embodiments of the invention relate to compositions comprising hyaluronidase and large diameter synthetic membrane vesicles containing a therapeutic agent, and methods of administration of the same. Methods of making large diameter synthetic membrane vesicles containing an active pharmaceutical ingredient and their use in combination with hyaluronidase as medicaments are provided.
Claims30
A pharmaceutical composition for enhancing the administration of a therapeutic agent in large diameter synthetic membrane vesicles, comprising
- hyaluronidase;
- and
- large diameter synthetic membrane vesicles, said large diameter synthetic membrane vesicles having encapsulated therein a therapeutic agent.
A method of enhancing the administration of a therapeutic agent in large diameter synthetic membrane vesicles to a subject in need thereof, comprising
- administering hyaluronidase to a subject;
- and,
- administering large diameter synthetic membrane vesicles having encapsulated therein a therapeutic agent to said subject,
- wherein ease of administration of said large diameter synthetic membrane vesicles is improved, or the volume of said large diameter synthetic membrane vesicles that can be administered is increased, in comparison to administration of said large diameter synthetic membrane vesicles in the absence of said hyaluronidase.
A kit for enhancing the administration of a therapeutic agent in large diameter synthetic membrane vesicles comprising a first sterile container comprising large diameter synthetic membrane vesicles, said large diameter synthetic membrane vesicles having encapsulated therein a therapeutic agent, and, a second sterile container comprising hyaluronidase.
A method of providing a therapeutic agent in large diameter synthetic membrane vesicles to an individual comprising:
- providing said individual large diameter synthetic membrane vesicles, said large diameter synthetic membrane vesicles having encapsulated therein a therapeutic agent,
- and providing said individual instructions to administer hyaluronidase prior to or concurrent with said large diameter synthetic membrane vesicles.
Dependencies are inferred from the claim text.