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US 2010/0305359 A1Published application
Processes For Preparing A Substituted Gamma-Amino Acid
AssigneeMedichem, S.A.
InventorBernardino Mangion
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Abstract
The present invention is related to processes suitable for industrial synthesis of pregabalin from (R)-(−)-3-(carbamoylmethyl)-5-methylhexanoic using sodium hypochlorite as described herein. In addition, the present invention is related to pregabalin which is substantially free of impurities and pharmaceutical compositions comprising pregabalin.
Claims19
A process for preparing pregabalin of Formula I:
- said process comprising reacting (R)-(−)-3-(carbamoylmethyl)-5-methylhexanoic of Formula II:
- with sodium hypochlorite at a temperature of from about 50° C. to about 70° C.
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Dependencies are inferred from the claim text.