Process for the preparation of an enantiomeric trisubstituted 3,4-dihydro-isoquinoline derivative

A process for the preparation of the compound of formula 7

• which process comprises the hydrogenation of the compound of formula 4
• in the presence of bis[chloro-1,5-cyclooctadiene-iridium], (S)-1-dicyclohexylphosphino-2-[(S)-α-(dimethylamino)-2-(dicyclohexylphosphino)benzyl]-ferrocene, iodine and a solvent, under hydrogen pressure of 1-200 bar, to obtain the compound of formula 7.