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OwnerYong Youn Hwang, Woo Jae Jang +4inventors
InventorsYong Youn Hwang, Woo Jae Jang, Joon-Gyo Oh, Nam Ho Kim, Jae-Sun Kim, Key An Um
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The present invention relates to a lyophilized pharmaceutical composition for injection having superior storage stability comprising a taxoid, and a method thereof. More specifically, the present invention relates to a lyophilized pharmaceutical composition for injection having improved solubility and stability of dilution compared to the conventional preparations by dissolving a water-insoluble taxoid in distilled water added with a hydrophilic polymer such as hydroxypropylmethyl cellulose (HPMC), polyethylene glycol (PEG) or polyvinylpyrrolidone (PVP) cyclodextrin (CD), and lyophilizing the mixture and a method thereof.
A lyophilized pharmaceutical composition comprising a water-insoluble taxoid, cyclodextrin, and at least one hydrophilic polymer selected from the group consisting of hydroxypropylmethyl cellulose (HPMC), polyethylene glycol (PEG), and polyvinylpyrrolidone (PVP).
A method of preparing a lyophilized pharmaceutical composition containing a taxoid, which comprises:
A method of preparing a pharmaceutical liquid composition for injection containing a taxoid, comprising:
Dependencies are inferred from the claim text.