Cationic lipids
AssigneeThe University Court of the University of Edinburg
InventorsMark Bradley, Asier Unciti-Broceta
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Abstract
This invention relates to cationic lipids. More particularly the invention relates to biodegradable cationic lipids having a plurality of cationic headgroups and one or more lipophilic tail groups. The lipids are of utility in various applications, and in particular in permitting transfection of molecules, and in particular DNA and RNA, into cells. As such the lipids have specific utility in the field of gene therapy as well as other applications such as delivery of small molecules into cells, detergents, and metal ion complexation for medical or industrial applications.
Claims53
A cationic lipid comprising a plurality of cationic moieties or cationic precursors within a plurality of headgroups, a lipophilic moiety and a linking moiety positioned between the lipophilic moiety and the headgroups, wherein the lipophilic moiety is connected to the linking moiety through a nitrogen-containing linkage and each of the headgroups is connected through an ester moiety to the linking moiety.
Dependencies are inferred from the claim text.