US 2010/0305193 A1Published application

Rnai-mediated inhibition of gremlin for treatment of iop-related conditions

AssigneeAlcon Research, Ltd.

InventorsJon E. Chatterton, Abbot F. Clark

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Abstract

RNA interference is provided for inhibition of gremlin in intraocular pressure-related conditions, including ocular hypertension and glaucoma such as normal tension glaucoma and open angle glaucoma.

Claims19

Dependent claims

A method of treating an IOP-related condition in a patient in need thereof, comprising administering to the patient an interfering RNA molecule that attenuates expression of the GREM1 mRNA via RNA interference.

Dependencies are inferred from the claim text.

Facts

Application: 12/791,926Filed 2 Jun 2010
Priority: 24 Aug 2006
Published: 2 Dec 2010
Term ends: Not estimatedThe source records don’t support an estimate.

Classification9 codes

A61K 31/7105
Compounds having three or more nucleosides or nucleotides: natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine,…
A61P 7/06
Drugs for disorders of the blood or the extracellular fluid: antianaemics
A61P 27/02
Drugs for disorders of the senses: ophthalmic agents
A61P 27/06
Ophthalmic agents: antiglaucoma agents or miotics

Family

Application60/839,826Us provisional application · filed 24 Aug 2006
Application11/844,869Division · filed 24 Aug 2007
Application12/791,926Division
US 2008/0051361 A1Published application
US 2010/0305193 A1This patent

From the US filing history. Foreign family members aren’t listed.

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