Compositions and methods for short interfering nucleic acid inhibition of nav1.8
AssigneesSchering Corporation, Canji, Inc.
InventorsSAMEER GOREGAOKER, JOHN C. HUNTER, TONY PRIESTLEY
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Abstract
The invention provides short interfering nucleic acids, either single-stranded or double-stranded, that cause RNAi-induced degradation of mRNA from the Nav1.8 sodium channel gene; to pharmaceutical compositions comprising such short interfering nucleic acids; recombinant vectors comprising such short interfering nucleic acids; a method for inhibiting translation of an mRNA; a method for inhibiting expression of a polypeptide; a method for blocking the membrane potential in a cell; a method for blocking the sodium current in a cell; and a method for inhibiting chronic pain.
Claims23
An isolated or recombinant short interfering nucleic acid comprising a nucleotide sequence selected from the group consisting of SEQ ID NOs:
- 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 and 11, or an analogue thereof.
An isolated or recombinant short interfering nucleic acid comprising a sense strand and an antisense strand, wherein said sense strand and said antisense strand hybridize to form a duplex, wherein said sense strand comprises a nucleotide sequence substantially identical to a target sequence, and wherein said target sequence is selected from the group consisting of SEQ ID NOs:
- 12-577.
Dependencies are inferred from the claim text.