Rna interference mediated inhibition of adenosine a1 receptor (adora1) gene expression using short interfering rna

A chemically modified short interfering ribonucleic acid (siRNA) molecule, wherein:

• (a) the siRNA molecule comprises a sense strand and a separate antisense strand;
• (b) each strand of the siRNA is independently 18 to 24 nucleotides in length, and the siRNA comprises between 17 and 23 base pairs;
• (c) one strand of the siRNA is complementary to a human ADORA1 RNA sequence;
• (d) 10 or more pyrimidine nucleotides of the sense and antisense strand are 2′-deoxy, 2′-O-methyl, or 2′-deoxy-2′-fluoro pyrimidine nucleotides;
• (e) the siRNA molecule comprises 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 phosphorothioate internucleotide linkages;
• and,
• (f) the sense strand of the siRNA molecule comprises a terminal cap molecule at the 3′-end, the 5′-end, or both of the 3′- and 5′-ends.