Methods and compounds for treating diseases caused by reactive oxygen species
AssigneeDeutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
InventorsKarsten Guelow, Marcin Kaminski, Michael Kiessling, Peter H. Krammer
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Abstract
Provided is a method of treating a patient having an inflammatory disease by using a compound which inhibits the complex I-mediated ROS production, a medicament containing such compound and methods for screening for such compounds.
Claims15
A method of treating a patient having an inflammatory disease, the method comprising administering to said patient a therapeutically effective amount of a compound which inhibits complex I-mediated ROS production.
A method of screening for a compound which inhibits complex I-mediated ROS production, the method comprising
- (a) contacting cells, particularly T-cells, with the compound under investigation,
- (b) staining said cells with an oxidation-sensitive dye, and
- (c) measuring the intensity of said dye
- wherein a decreasing intensity as compared to cells that are not contacted with said compound is indicative of an inhibitory effect of said compound.
Use of a compound which inhibits complex I-mediated ROS production for the preparation of a pharmaceutical agent for treating a patient having an inflammatory disease.
A method for manufacturing a medicament against an inflammatory disease, the medicament containing a therapeutically effective amount of a compound which inhibits complex I-mediated ROS production.
A medicament against an inflammatory disease, the medicament containing a therapeutically effective amount of a compound which inhibits complex I-mediated ROS production.
Dependencies are inferred from the claim text.