Method and composition for reducing reperfusion injury
AssigneesAdelaide Research & Innovation Pty Ltd, James Cook University
InventorsAlan John Nimmo, Karen Margaret Whitfield, Renée Jade Turner, Robert Vink
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Abstract
The present invention relates to a method of preventing and/or reducing reperfusion injury to a tissue, organ, or organ system in a subject. The method includes administering to the subject an effective amount of a substance P receptor antagonist.
Claims56
A method of preventing and/or reducing reperfusion injury to a tissue, organ, or organ system in a subject, the method including administering to the subject an effective amount of a substance P receptor antagonist.
Use of a substance P receptor antagonist in the preparation of a medicament for preventing and/or reducing reperfusion injury.
Use of a substance P receptor antagonist and a thrombolytic agent in the preparation of a medicament for preventing and/or treating a thrombo-embolic occlusion.
Use of a substance P receptor antagonist and a thrombolytic agent in the preparation of a medicament for preventing and/or treating stroke.
A combination product including the following components:
- a substance P receptor antagonist;
- and
- a thrombolytic agent;
- wherein the components are provided in a form for separate administration to a subject, or in a form for co-administration to a subject.
A pharmaceutical composition including an effective amount of a substance P receptor antagonist and a thrombolytic agent.
A method of preventing and/or reducing oedema to a tissue, organ or organ system in a subject due to reperfusion of the tissue, organ or organ system, the method including administering to the subject an effective amount of a substance P receptor antagonist.
Use of a substance P receptor antagonist in the preparation of a medicament for preventing and/or reducing oedema due to reperfusion of a tissue, organ or organ system.
A method of preventing and/or reducing an inflammatory response in a tissue, organ or organ system in a subject due to reperfusion of the tissue, organ or organ system, the method including delivering to the tissue, organ or organ system an effective amount of a substance P receptor antagonist.
Use of a substance P receptor antagonist in the preparation of a medicament for preventing and/or reducing an inflammatory response in a tissue, organ or organ system due to reperfusion of the tissue, organ or organ system.
A method of treating a thrombo-embolic occlusion in a subject, the method including administering to the subject an effective amount of a substance P receptor antagonist and a thrombolytic agent.
A method of treating an thrombo-embolic stroke in a subject, the method including administering to the subject an effective amount of a substance P receptor antagonist and a thrombolytic agent.
Use of a substance P receptor antagonist and a thrombolytic agent in the preparation of a medicament for treating a thrombo-embolic stroke.
A method of improving the prognosis or outcome of a subject suffering from a thrombo-embolic occlusion, the method including administering to the subject an effective amount of a substance P receptor antagonist and a thrombolytic agent.
Dependencies are inferred from the claim text.