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OwnerRamesh Krishnamoorthy, Leo A. Trevino +1inventors
InventorsRamesh Krishnamoorthy, Leo A. Trevino, Richard M. Evans
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The present invention relates to an aqueous pharmaceutical formulation comprising at least one latrunculin and the formulation does not contain a substantial amount of dimethyl sulfoxide. In one embodiment, the present invention is directed to an aqueous pharmaceutical formulation comprising at least one latrunculin in an amount of 0.001-2% w/v, a non-ionic surfactant in an amount of 0.01-2% w/v, and a tonicity agent to maintain a tonicity between 200-400 mOsm/kG, at a pH between 4 to 8, wherein the latrunculin, the surfactant, and the tonicity agent are compatible in the formulation, and the formulation does not contain a substantial amount of dimethyl sulfoxide. The formulation is stable for at least six month at refrigerated temperature. The present invention further provides a method of reducing intraocular pressure, a method of treating glaucoma, a method of inhibiting wound healing after trabeculectomy, and a method of inhibiting angiogenesis.
An aqueous pharmaceutical formulation comprising at least one latrunculin in an amount of 0.001-2% w/v, a non-ionic surfactant selected from the group consisting of polysorbates, tyloxapol, polyoxyl castor oil, polaxamers, and polyoxyl stearates, in an amount of 0.01-2% w/v, and a non-ionic tonicity agent to maintain a tonicity between 200-400 mOsm/kG, at a pH between 4 to 8, wherein the latrunculin, the surfactant, and the tonicity agent are compatible in the formulation, and the formulation does not contain more than 0.1% v/v of dimethyl sulfoxide.
An aqueous pharmaceutical formulation comprising at least one latrunculin in an amount of 0.001-2% w/v, 0.05-1.5% w/v of polysorbate, 4-5% w/v of mannitol, 5-50 mM of citrate, 0.005-0.5% w/v of EDTA, and 0.001-1% w/v benzethonium chloride, wherein the formulation has a pH of 4-6 and does not contain more than 0.01% v/v of DMSO.
Dependencies are inferred from the claim text.