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US 2010/0305171 A1Published application
Methods for Concomitant Administration of Colchicine and a Second Active Agent
AssigneeMutual Pharmaceutical Company, Inc.
InventorMatthew W. Davis
Life of this patent
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Abstract
Methods for concomitant administration of colchicine together with one or more second active agents, e.g., ketoconazole and ritonavir, are disclosed. Such methods reduce the dangers commonly associated with such concomitant administration and provide additional benefits. Methods of notifying health care practitioners and patients regarding appropriate dosing for concomitant administration of colchicine together with second active agents are also provided.
Claims1
A method of treating a patient in need of treatment for gout flares with colchicine, comprising
- orally administering to the patient in need of treatment for gout flares, an adjusted daily dosage amount of colchicine to the patient who is receiving concomitant administration of 200 mg per day of ritonavir,
- wherein the adjusted daily dosage amount of colchicine is a 0.6 mg dose, dose to be repeated no earlier than 3 days, which is a two thirds reduction of an intended daily dosage amount in the absence of concomitant ritonavir which is 1.2 mg at the first sign of flare, followed by 0.6 mg one hour later, dose to be repeated no earlier than 3 days.
Dependencies are inferred from the claim text.