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US 2010/0305166 A1Published application
Novel compounds
AssigneeGlaxo Group Limited
InventorsAlessandra Gaiba, Susan Roomans, Martin Edward Swarbrick
Life of this patent
Estimating the term…
Abstract
A compound of formula (I) or salts thereof, wherein R1, R2, R3, R4, n and X are as defined in the specification; a process for preparing such compounds, a pharmaceutical composition comprising such compounds; and the use of such compounds in medicine.
Claims13
A compound of formula (I) or pharmaceutically acceptable salts thereof,
- wherein
- R1 is H, or halo or C1-4 alkyl;
- R2 is a 4 to 6 membered non-aromatic carbocylic group, or phenyl, or pyridinyl;
- which carbocylic or pyridinyl group is optionally substituted with one or two substituents, which may be the same or different, selected from the group consisting of:
- halo, C1-4 alkyl, C1-4 alkoxy, halo C1-4 alkyl and halo C1-4 alkoxy;
- or which phenyl group is substituted with one or two substituents, which may be the same or different, selected from the group consisting of:
- halo, C1-4 alkyl, C1-4 alkoxy, halo C1-4 alkyl and halo C1-4 alkoxy;
- R3 is halo;
- R4 is COOH, CH2COOH or tetrazolyl;
- X is C or N;
- and
- n is 0 or 1;
- with the proviso that when R4 is in the 4 position on the ring, it cannot be CH2COOH;
- and
- when R4 is in the 3 position on the ring, R2 is not 4-chloro-phenyl.
12 more elements
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Dependencies are inferred from the claim text.