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US 2010/0305155 A1Published application
Substituted pyrazole inhibitors of c-met protein kinase
AssigneeVertex Pharmaceuticals Incorporated
InventorsPan Li, Nathan Waal, Steven Ronkin, Qing Tang, David Lauffer
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Abstract
The present invention relates to compounds of formula I, which is useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising compounds of formula I and methods of using the compositions in the treatment of proliferative disorders.
Claims18
A compound having the formula:
- or a pharmaceutically acceptable salt thereof, wherein
- R1 is cyclopropyl or C1-3 aliphatic, optionally substituted with 1-3 fluorine atoms;
- R2 is hydrogen, fluoro, or methyl;
- R3 is hydrogen, fluoro, or methyl;
- and
- R4 is hydrogen or fluoro.
3 more elements
Dependencies are inferred from the claim text.