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US 2010/0305144 A1Published application
Prevention of recurrence of urethral stricture after a conventional treatment
AssigneeWindgan Trading Ltd
InventorMehdi Jaidane
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AssigneeWindgan Trading Ltd
InventorMehdi Jaidane
Estimating the term…
Prevention of recurrence of urethral stricture after a conventional treatment. Composition applicable to the prevention of recurrence of urethral stricture after a conventional treatment, including a pharmaceutically effective amount of halofuginone. Urethral stricture, a common disease, appears secondary to urethritis, urethral infection, urethral inflammation, urethral instrumentation, urethral catheterization, urethral trauma, urethral surgery and all types of urethral lesions. Conventional treatments by internal urethrotomy, urethral dilation or surgical urethroplasty are available and can cure urethral stricture, but with a relatively high rate of recurrence of the stricture. Halofuginone can prevent the recurrence of urethral stricture after a conventional treatment via internal urethrotomy, urethral dilation or surgical urethroplasty.
1- A composition suitable for preventing the recurrence of urethral strictures in a subject following initial therapy with internal urethrotomy, urethral dilatation or surgical urethroplasty, the method comprising the step of administering to said subject a pharmaceutically effective amount of a compound having the formula:
2- The composition according to claim 1, wherein the said composition contains Halofuginone.
3- The composition according to claim 1, wherein the said composition is administered to the subject by a route selected from the group consisting of the oral, parenteral and topical routes.
4- The composition according to claim 3, wherein the said composition is administered to the subject by topical intra-urethral application.
5- composition according to claim 4, wherein the said composition comprises a pharmaceutical carrier selected from the group consisting of a gel, a liquid, a lotion, a cream, an ointment and a spray.
6- composition according to claim 5, wherein the said composition is administered to the subject until the prevention of urethral stricture recurrence is achieved.