Quinolone analogs derivatized with sulfonic acid, sulfonate or sulfonamide

A compound having formula (1), (3A), or (3B):

• or a pharmaceutically acceptable salt thereof;
• wherein B, X, A, or V is absent if Z1, Z2, Z3, or Z4 respectively is N, and independently H, halo, azido, R2, CH2R2, SR2, OR2 or NR1R2 when Z1, Z2, Z3, or Z4 respectively is C;
• or
• A and V, A and X, or X and B may form a carbocyclic ring, heterocyclic ring, aryl or heteroaryl, each of which may be optionally substituted and/or fused with a cyclic ring;
• each Z is O, S, NR1, CH2, or C═O;
• Z1, Z2, Z3 and Z4 are C or N, provided any three N are non-adjacent;
• each W together with N and Z forms an optionally substituted 5- or 6-membered ring that is fused to an optionally substituted saturated or unsaturated ring;
• said saturated or unsaturated ring may contain a heteroatom and is monocyclic or fused with a single or multiple carbocyclic or heterocyclic rings;
• each U is —SO3R2, —SO2NR1R2, —SO2NR1NR1R2, —SO2NR1OR2, SO2NR1—(CR12)n—NR3R4, SO2NR1NR1—(CR12)n—NR3R4 or SO2NR1O—(CR12)n—NR3R;
• in each NR1R2, R1 and R2 together with N may form an optionally substituted ring;
• in NR3R4, R3 and R4 together with N may form an optionally substituted ring;
• R1 and R3 are independently H or C1-6 alkyl;
• each R2 is H, or a C1-10 alkyl or C2-10 alkenyl each optionally substituted with a halogen, one or more non-adjacent heteroatoms, a carbocyclic ring, a heterocyclic ring, an aryl or heteroaryl, wherein each ring is optionally substituted;
• or R2 is an optionally substituted carbocyclic ring, heterocyclic ring, aryl or heteroaryl;
• R4 is H, a C1-10 alkyl or C2-10 alkenyl optionally containing one or more non-adjacent heteroatoms selected from N, O and S, and optionally substituted with a carbocyclic or heterocyclic ring;
• or R3 and R4 together with N may form an optionally substituted ring;
• each R5 is a substituent at any position on ring W;
• and is H, OR2, amino, alkoxy, amido, halogen, cyano or an inorganic substituent;
• or R5 is C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, —CONHR1, each optionally substituted by halo, carbonyl or one or more non-adjacent heteroatoms;
• or two adjacent R5 are linked to obtain a 5-6 membered optionally substituted carbocyclic or heterocyclic ring that may be fused to an additional optionally substituted carbocyclic or heterocyclic ring;
• and
• n is 1-6.