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US 2010/0305135 A1Published application
Ahcy hydrolase inhibitors for treatment of hyper homocysteinemia
AssigneeMerck & Co., Inc.
InventorsRobert M. Garbaccio, Antonella Converso, Mark E. Fraley, Timothy J. Hartingh
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Abstract
The present invention is directed to AHCY inhibitors of formula (I) which are useful in the treatment of diseases characterized by high homocysteine levels, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases characterized by high homocysteine levels.
Claims12
A compound of formula (I):
- or a pharmaceutically acceptable salt thereof, wherein
- X—Y is selected from the group consisting of
- (1) CH2—CR1R2,
- (2) CH═CR1;
- R1 is selected from the group consisting of
- (1) hydrogen,
- (2) hydroxyl,
- (3) —C1-6 alkyl, wherein said alkyl is optionally substituted with
- (a) halogen, or
- (b) hydroxyl;
- and
- R2 is selected from the group consisting of
- (1) hydrogen,
- (2) hydroxyl,
- (3) —C1-6 alkyl, wherein said alkyl is optionally substituted with
- (a) halogen, or
- (b) hydroxyl.
14 more elements
(canceled)
(canceled)
Dependencies are inferred from the claim text.