Compounds Comprising a Cyclobutoxy Group

A compound of formula (I′), geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,

• wherein
• A1 is CH, C-halogen or N;
• A2 is oxygen or sulfur;
• X is O, S, NH or N(C1-4 alkyl);
• R1 is hydrogen, halogen, C1-4 alkyl or C1-4 alkoxy;
• R2a is hydrogen, C1-6 alkyl, C1-6-alkyl cycloalkyl, aryl, C2-6 alkenyl, heteroaryl, C3-8 cycloalkyl, 3-8-membered heterocycloalkyl, acyl, C1-6-alkyl aryl, C1-6-alkyl heteroaryl, C1-6-alkyl heterocycloalkyl, alkoxycarbonyl, aminocarbonyl, C1-6-alkyl acyl, C1-6-alkyl alkoxy, C1-6-alkyl alkoxycarbonyl, C1-6-alkyl aminocarbonyl, C1-6-alkyl acylamino, C1-6-alkyl ureido, C1-6-alkyl aminocarbonyloxy, C1-6-alkyl aminocarbonylthio, C1-6-alkyl carbamate, C1-6-alkyl amino, C3-8-cycloalkyl amino, C1-6-alkyl hydroxy or cyano;
• R2b is hydrogen, C1-8 alkyl or C3-8 cycloalkyl;
• or R2a and R2b are linked together to form a C3-8 cycloalkyl or a 3-8 membered heterocycloalkyl;
• A is a substituted or unsubstituted aliphatic or cyclic amino group which is linked to the cyclobutyl group via an amino nitrogen;
• L1 is —(O)v—(CR9aR9b)m—(CH2)z;
• R9a is hydrogen or C1-8 alkyl;
• R9b is a C1-6-alkyl aryl or C1-8 alkyl;
• n is an integer equal to 0 or 1;
• v is an integer equal to 0 or 1;
• m is an integer equal to 0 or 1;
• z is an integer equal to 0, 1, 2 or 3.