Phenylsulfoxyoxazole compound inhibitors of urea transporters
AssigneeThe Regents of the University of California
InventorsAlan S. Verkman, Marc Harris Levin
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Abstract
Provided herein are small molecule compounds that alter the transport activity of solute transporters, particularly urea transporters. The compounds described herein belong to the phenylsulfoxyoxazole, phenylsulfoxyimidazole, phenylsulfoxythiazole class of compounds. The compounds described herein are useful for increasing solute clearance in states of fluid overload and for treating cardiovascular, renal, and metabolic diseases, disorders, and conditions. Methods for identifying and using these agents that inhibit urea transporters are described herein.
Claims91
A composition comprising a physiologically acceptable excipient and a compound having the following structure (I):
- or a pharmaceutically acceptable salt, prodrug or stereoisomer thereof,
- wherein
- X is NR8, O, or S;
- R1 is hydrogen, hydroxyl, halogen, alkyl, aryl, arylalkyl, arylalkylamino, sulfhydryl, thioalkyl, amino, alkylamino, amidyl, heterocycle, or heterocycloalkyl;
- R2 is hydrogen, hydroxyl, halogen, alkyl, aryl, arylalkyl, arylalkylamino, heterocycle or heterocyclealkyl;
- R3, R4, R5, R6 and R7 are each the same or different and independently hydrogen, halogen or alkyl;
- and
- R8 is hydrogen or alkyl.
Dependencies are inferred from the claim text.