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US 2010/0305104 A1Published application
Oxadiazole Diaryl Compounds
AssigneeMerck Serono SA
InventorsCyril Montagne, Anna Quattropani, Wolfgang Sauer, Agnes Bombrun
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Abstract
The invention relates to compounds of formula (I): wherein R1, R2, Ra, Rb, Rc and W, have the meanings given in claim 16. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis.
Claims16
1-15. (canceled)
A compound of Formula I
- wherein:
- R1, R2 denote H, Hal, CF3, OCF3, CN, or NO2,
- W denotes CH or N,
- Ra is Ar, Het, cycloalkyl having 3-7 atoms, A or NA2,
- Rb is H, A, Hal, CF3, OCF3, OR3, CN, NO2, (CH2)nN(R3)2, OA, (CH2)nSO2N(R3)2, (CH2)nNR3SO2A, (CH2)nN(SO2A)2, NR3CON(R3)2, NR3COA or (CH2)nSO2R3,
- Re denotes A, COA, CSA, COOA, CSOA, CON(R3)2 or CSN(R3)2,
- A is branched or linear alkyl having 1 to 12 C-atoms, wherein one or more, H-atoms may be replaced by Hal, or 1 to 7H-atoms may be replaced by OR3, CN or N(R3)2 and wherein one or more, preferably 1 to 7 non-adjacent CH2-groups may be replaced by O, NR3 or S and/or by —CH═CH— or —C≡C— groups, or denotes cycloalkyl or cycloalkylalkylene having 3-7 ring C atoms,
- Hal is F, Cl, Br or I,
- Ar denotes a monocyclic or bicyclic, unsaturated or aromatic carbocyclic ring having 6 to 14 carbon atoms which may be unsubstituted or monosubstituted, disubstituted or trisubstituted by Hal, A, CH2OA, CH2N(R3)2, OR3, N(R3)2, NO2, N(SO2Me)2, CN, COOR3, CF3, OCF3, CON(R3)2, NR3COA, NR3CON(R3)2, NR3SO2A, COR3, SO2N(R3)2, SOA or SO2A, phenyl, pyridyl-[C(R3)2]n—COOR3 and/or —O[C(R3)2]n—CON(R3)2,
- Het denotes a monocyclic or bicyclic, saturated, unsaturated or aromatic heterocyclic ring having 1 N and/or 1 to 3O and/or S atoms which may be unsubstituted or monosubstituted, disubstituted or trisubstituted by Hal, A, —[C(R3)2]n—Ar, —[C(R3)2]n-cycloalkyl, CH2OA, CH2N(R3)2, OR3, CF3, OCF3, N(R3)2, N(SO2Me)2, NR3CON(R3)2, NO2, CN, —[C(R3)2]n—COOR3, —[C(R3)2]n—CON(R3)2, NR3COA, NR3SO2A, COR3, SO2N(R3)2, SOA, phenyl, pyridyl and/or SO2A,
- R3 is H or A,
- and
- n is 0, 1, 2, 3, 4, 5, 6, 7 or 8,
- and pharmaceutically acceptable solvates, tautomers, salts and stereoisomers thereof, including mixtures thereof in all ratios.
11 more elements
Dependencies are inferred from the claim text.