PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES

A compound of formula I:

• or a pharmaceutically acceptable salt or hydrate thereof;
• wherein:
• A represents a mono- or bicyclic aromatic ring system of up to 10 ring atoms, of which 0-3 are heteroatoms independently selected from O, N and S, which bears 0-3 substituents independently selected from halogen, CN, C1-4alkyl, CF3 and C1-4alkoxy;
• X represents a monocyclic or bicyclic ring system comprising up to 10 ring atoms, of which 1-3 are selected from N, O and S and the remainder are C, said ring system bearing 0-3 substituents independently selected from halogen, CN, R1-L, R10-L, R1R2N-L and R1CONR2;
• L represents a bond or a linking group selected from CO, (CO)m(CH2)n, (CO)m(CH2)nO, (CO)m(CH2)nNR2 and (CO)m(CH2)nS;
• m is 0 or 1;
• n is 0, 1, 2, 3 or 4;
• R1 is selected from:
• H;
• C1-6alkyl which is optionally substituted with up to 3 halogen atoms or with OH, CN, C3-6cycloalkyl, C1-4alkoxy, C1-4alkoxycarbonyl, amino, C1-4alkylamino or di(C1-4alkyl)amino;
• and
• phenyl or C3-6cycloalkyl, either of which is optionally substituted with up to 3 halogen atoms or with OH, CN, CF3, C1-4alkyl, C1-4alkoxy, C1-4alkoxycarbonyl, amino, C1-4alkylamino or di(C1-4alkyl)amino;
• R2 represents H or C1-4alkyl;
• or R1 and R2 attached to the same nitrogen atom may complete a heterocycle of up to 7 ring atoms which is optionally substituted with up to 3 halogen atoms or with OH, CN, CF3, C1-4alkyl, C1-4alkoxy, C1-4alkoxycarbonyl, amino, C1-4alkylamino or di(C1-4alkyl)amino;
• R3 represents H or C1-4alkyl which is optionally substituted with OH, CN, CF3, C1-4alkoxy, amino, C1-4alkylamino or di(C1-4alkyl)amino;
• R4 is selected from:
• (i) H;
• (ii) C1-8alkyl or C2-8alkenyl, either of which optionally bears up to 3 substituents independently selected from halogen, OH, CN, CF3, OR6, SR7, SO2R7, SO2N(R6)2, COR6, CO2R6, CON(R6)2, N(R6)2, NR6COR7 and NR6SO2R7;
• and
• (iii) C3-10cycloalkyl, C3-10cycloalkylC1-4alkyl, Het, HetC1-4alkyl, aryl or arylC1-4alkyl, any of which optionally bears up to 3 substituents independently selected from halogen, OH, oxo, CN, CF3, R7, OR6, SR7, SO2R7, SO2N(R6)2, COR6, CO2R6, CON(R6)2, N(R6)2, NR6COR7 and NR6SO2R7;
• where “aryl” refers to phenyl or 5- or 6-membered heteroaryl, either of which phenyl or heteroaryl is optionally fused to a 5- or 6-membered carbocycle or heterocycle, and “Het” refers to a nonaromatic mono- or bicyclic heterocyclic system of up to 10 ring atoms;
• or R3 and R4 together may complete a mono- or bicyclic heterocyclic system of up to 10 ring atoms which optionally bears up to 3 substituents independently selected from halogen, OH, oxo, CN, CF3, R7, OR6, SR7, SO2R7, SO2N(R6)2, COR6, CO2R6, CON(R6)2, N(R6)2, NR6COR7 and NR6SO2R7;
• R6 represents H or C1-6alkyl which is optionally substituted with up to 3 halogen atoms or with OH, CN, CF3, C1-4alkoxy, amino, C1-4alkylamino or di(C1-4alkyl)amino, or R6 represents phenyl, benzyl or 5- or 6-membered heteroaryl, any of which optionally bears up to 3 substituents independently selected from halogen, OH, CN, CF3, C1-4alkyl, C1-4alkoxy, amino, C1-4alkylamino and di(C1-4alkyl)amino;
• or two R6 groups attached to the same nitrogen atom may complete a heterocycle of up to 6 ring atoms which optionally bears up to 3 substituents independently selected from halogen, OH, oxo, CN, CF3, C1-4alkyl, C1-4alkoxy, amino, C1-4alkylamino and di(C1-4alkyl)amino;
• and
• R7 has the same definition as R6 except that R7 is not H.