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US 2010/0305077 A1Published application
Compounds for the selective treatment of the intestinal immuno-inflammatory component of the celiac disease
AssigneeGiuliani International Limited
InventorsSergio Baroni, Salvatore Bellinvia
Life of this patent
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Abstract
In one aspect, the present invention relates to amino-salicylic-aminophenylpropionic compounds for the use in the treatment of the inflammatory component of the celiac disease. These compounds act by blocking the cytokines released in the celiac disease and are specifically useful in the treatment of cases refractory to the diet, in dietary errors and in the reduction of the celiac disease remission time.
Claims28
A compound of formula (I)
- wherein
- R1 and R2, equal or different from each other, are selected from the group comprising —H or a linear or branched alkyl group having 1 to 6 carbons, or together they form an aromatic or aliphatic ring with 5 or 6 atoms,
- Y and Z, equal or different from each other, are selected from the group comprising —H, —OH, —COON, —OR3, —CH(OR3)COOH,
- wherein R3 is selected from H, phenyl, benzyl, —CF3, —CF2CF3, vinyl, allyl, a linear or branched alkyl group having 1 to 6 carbons,
- or mixtures thereof and pharmaceutically acceptable salts or esters, for the use in the treatment of the inflammatory component of the celiac disease.
2 more elements
A compound of formula (II)
- wherein
- R1 and R2, equal or different from each other, are selected from the group comprising —H, —CO—CH3, —CnH2n−1 with n from 1 to 6, a linear or branched alkyl group having 1 to 6 carbons, or together they form an aromatic or aliphatic ring with 5 or 6 atoms;
- R3 is selected from H, —CO—CH3, —NHOH, —OH, —OR6, wherein R6 is a linear or branched alkyl group having 1 to 6 carbons;
- R4 is selected from H, a linear or branched alkyl group having 1 to 6 carbons, phenyl, benzyl, —CF3, —CF2CF3, vinyl or allyl;
- R5, R7, R8 are H atoms;
- or
- R3 and R4, R4 and R5, or R7 and R8 together form a ring, fused to the benzene ring, either aromatic or aliphatic with 5 or 6 atoms comprising 1 to 2 heteroatoms independently selected from the group consisting of N, O
- or mixtures thereof and their pharmaceutically acceptable salts or esters,
- for the use in the treatment of the inflammatory component of the celiac disease.
6 more elements
Dependencies are inferred from the claim text.