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US 2010/0305060 A1Published application
Nucleoside Prodrugs and Uses Thereof
AssigneeLigand Pharmaceuticals Incorporated
InventorsScott J. Hecker, K. Raja Reddy
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Abstract
This application provides compositions or compounds as disclosed herein that are suitable for treating hepatic viral diseases, such as hepatitis C(HCV).
Claims12
1-10. (canceled)
A compound of general formula III
- wherein
- V is selected from the group consisting of phenyl and monocyclic heteroaryl, wherein (i) each said monocyclic heteroaryl contains five or six ring atoms of which 1 or 2 ring atoms are heteroatoms selected from the group consisting of N, S, and O, and the remainder of the ring atoms are carbon, and (ii) each said phenyl or monocyclic heteroaryl is unsubstituted or is substituted by one or two groups selected from halogen, trifluoromethyl, C1-C6 alkyl, C1-C6 alkoxy, and cyano;
- B is
- R1 is selected from H and CORS;
- Y is O or NH;
- R2 is C1-C6 alkyl or CORS;
- and
- R3 is C1-C6 alkyl;
- or a pharmaceutically acceptable salt thereof.
6 more elements
Dependencies are inferred from the claim text.