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US 2010/0305052 A1Published application
Substituted 4-aryl-1,4-dihydro-1,6-naphthyridines and use thereof
AssigneeBayer Schering Pharma Aktiengesellschaft
InventorsSantiago Figueroa Perez, Peter Kolkhof, Lars Bärfacker, Ingo Flamme, Karl-Heinz Schlemmer, Rolf Grosser, Klaus Münter, Andreas Knorr
Life of this patent
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Abstract
The present application relates to novel substituted 4-aryl-1,4-dihydro-1,6-naphthyridines, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.
Claims9
A compound of the formula (I)
- in which
- Ar is a group of the formula
- in which
- * is the linkage point,
- R5 is hydrogen or halogen,
- R6 is methyl or ethyl,
- R7 is hydrogen, fluorine, chlorine, cyano, nitro, trifluoromethyl or (C1-C4)-alkyl,
- R8 is hydrogen or fluorine,
- R9 is halogen, (C1-C4)-alkyl, trifluoromethyl, (C1-C4)-alkoxy or trifluoromethoxy,
- R10 is cyano or nitro,
- R11 is hydrogen, halogen, (C1-C4)-alkyl, (C1-C4)-alkoxy, (C1-C4)-alkylthio or di-(C1-C4)-alkylamino, it being possible for the alkyl group in said (C1-C4)-alkyl, (C1-C4)-alkoxy and (C1-C4)-alkylthio radicals in each case to be substituted up to three times by fluorine,
- or
- phenyl, which may be substituted by halogen, (C1-C4)-alkyl or trifluoromethyl,
- R12 is hydrogen, halogen or (C1-C4)-alkyl,
- D is CH, C—R9 or N,
- and
- n is the number 0, 1 or 2,
- it being possible in the case where the substituent R9 occurs more than once for its meanings to be identical or different,
- R1 is cyano, nitro or a group of the formula —C(═O)—R13 in which
- R13 is (C1-C6)-alkyl which may be substituted by (C3-C7)-cycloalkyl or once to three times by fluorine, or phenyl which may be substituted by halogen, cyano, (C1-C4)-alkyl, trifluoromethyl, (C1-C4)-alkoxy or trifluoromethoxy, or (C3-C7)-cycloalkyl,
- R2 is (C1-C4)-alkyl, trifluoromethyl, cyclopropyl, cyclobutyl, (C1-C4)-alkoxy or (C1-C4)-alkylthio,
- R3 is (C1-C6)-alkyl, (C1-C6)-alkoxy, trifluoromethoxy, (C1-C6)-alkylthio, amino, mono-(C1-C6)-alkylamino or a group of the formula —O—SO2—R14,
- where said (C1-C6)-alkyl, (C1-C6)-alkoxy and (C1-C6)-alkylthio radicals may in each case be substituted by (C3-C7)-cycloalkyl,
- and
- R14 is (C1-C6)-alkyl, trifluoromethyl, (C3-C7)-cycloalkyl, phenyl or 5- or 6-membered heteroaryl having up to two heteroatoms from the series N, O and/or S,
- it being possible for phenyl and heteroaryl in turn each to be substituted once or twice, identically or differently, by halogen, cyano, nitro, (C1-C4)-alkyl, trifluoromethyl, (C1-C4)-alkoxy and/or trifluoromethoxy,
- and
- R4 is hydrogen, fluorine, (C1-C4)-alkyl, trifluoromethyl, (C1-C4)-alkoxy, trifluoromethoxy, (C1-C4)-alkylthio, amino, mono-(C1-C4)-alkylamino or di-(C1-C4)-alkylamino,
- and the salts thereof.
26 more elements
5-6. (canceled)
(canceled)
Dependencies are inferred from the claim text.