Novel use of cytokine inhibitors
AssigneePharmaSurgics in Sweden AB
InventorKjell OLMARKER
Life of this patent
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Abstract
The use of substance that inhibits a pro-inflammatory cytokine, such as TNF or IL-1, for the production of a pharmaceutical composition for improving wound healing is disclosed. Also, a method for improving wound healing wherein a therapeutically effective amount of a substance that inhibits a pro-inflammatory cytokine is administered to a patient in need of said treatment is disclosed.
Claims11
1-45. (canceled)
A method for treating a wound and/or improving healing comprising administering a therapeutically effective amount of a pharmaceutical composition comprising a peptide derived from amino acid 12 to amino acid 40 of human lactoferrin to a patient in need thereof, wherein:
- said peptide inhibits a pro-inflammatory cytokine;
- said peptide comprises 20Cys-Phe-X1-X-2-X3-X4-X5-X6-X7-Lys-Val-Arg31 (SEQ ID NO:
- 99), wherein X1 is Gln or Ala;
- X2 is Trp or Leu;
- X3 is Gln, Lys, Orn, Ala, or Nle;
- X4 is Arg, Lys, or Ala;
- X5 is Asn, Orn, Ala, or Nle;
- X6 is Met or Leu;
- and X7 is Arg or Lys;
- and
- said peptide is selected from the group consisting of SEQ ID NOS:
- 2-5, 8, 31-37, 47, 49, 51, 63, 65, 67, 70, 72-74, 80-83, and 87-97.
47-48. (canceled)
Dependencies are inferred from the claim text.